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Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model

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Pre-clinical research conducted primarily in animal models informs the hypotheses for its use, but no large randomized controlled trials in humans have confirmed efficacy for any outcome - including gut-lining support, tissue-related processes, or any other claimed mechanism

It is not approved for human consumption or therapeutic use in the UK

Liver fat fell up to 47% at 15 mg in a fatty-liver diabetes substudy, a figure that only lands for someone who has liver fat to lose

Most of the early studies focused on its effects on the stomach and intestines