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Exp Opin Drug Safety 2020;19(12):1641-9

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IGF-1 LR3 binds the alpha subunit of the IGF-1 receptor tyrosine kinase, inducing autophosphorylation of the beta subunit on specific tyrosine residues (Y1131, Y1135, Y1136) that create docking sites for insulin receptor substrate (IRS) proteins and Shc adaptor proteins

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Unpaired t test was performed using GraphPad Prism v9.4.0.673 for Windows (GraphPad Software, San Diego, California USA)

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Chen, T.-H., Wang, H.-C., Chang, C.-J., & Lee, S.-Y

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The optimal precursor (NMN vs NR), dose, and duration remain debated

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