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The shared core: stimulating the bodys own pulsatile GH Native GHRH is released from the hypothalamus in bursts and binds the GHRH receptor on pituitary somatotrophs, triggering GH secretion

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GHRP-2 and GHRP-6 are synthetic growth hormone-releasing peptides, agonists of the ghrelin receptor (GHS-R)

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Moreover, proteases originating from gut bacteria could have a role in the gut barrier function, probably via damage to the gut mucus layer and junction proteins