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Mild fatigue and slightly fragmented sleep during days 4-10 post-cessation is expected and reflects the temporary dip in endogenous GH pulse amplitude during pituitary recalibration

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Several studies have shown that the expression and/or activity of CBS is tightly regulated and strongly depends on the redox state of the cell (Mosharov et al., 2000

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Tholier, J., Fliss, I., Jean, J

It acts at the GHRH receptor on pituitary somatotroph cells and has been studied for its role in stimulating endogenous growth hormone release and downstream IGF-1 production