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staggered titration Cycle driver GI tolerance sets the pace Tirzepatide Loading 2.5 5 7.5 10 12.5 mg (every 4 weeks) Frequency Once weekly Maintenance 15 mg weekly Route SubQ Cagrilintide Loading Start Week 9: 0.25 0.5 1.0 1.7 mg Frequency Once weekly Maintenance 2.4 mg weekly Route SubQ Weekly Schedule Example (Maintenance Phase) Monday Tirzepatide 15 mg (one site) + Cagrilintide 2.4 mg (different site) Tuesday No injections Wednesday No injections Thursday No injections Friday No injections Saturday No injections Sunday No injections Both compounds are once weekly

Yet variability in quality, oversight, and pricing creates risk for both patients and physicians

visualization, M.A.A

2 New England Journal of Medicine REDEFINE 2Davies M et al

BPC-157 has been in its first human clinical trial since 2025 (Phase 1, USA)

Eligibility is determined after a thorough medical evaluation to ensure safety and realistic expectations