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Serum B12 alone can be misleading, while methylmalonic acid levels offer a more accurate assessment of whether the body is utilizing available B12

Biochim Biophys Acta 1586:344352 Halliwell B, Gutteridge JMC (2007) Oxidative stress: adaptation, damage, repair and death

These results suggest that activation of sphingosine-1-phosphate receptor 2 inhibits remyelination and exacerbates BBB permeability and demyelination

So methylene blue is like an army of the shady taxis

They also found a positive correlation between NOx metabolites and disease progression measured by urticaria activity score (UAS) (27)

doi:10.1002/cphy.c130024 [PubMed][CrossRef] 111