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Multiple coenzymes are required in some pathways, for example, the synthesis of catecholamines from tyrosine requires tetrahydrobiopterin (BH4), pyridoxal phosphate (PLP, a derivative of vitamin B6), ascorbate (vitamin C) and the co-substrate S-adenosylmethionine (SAM) as the methyl group donor in the final methylation step from norepinephrine to epinephrine
Many standard supplements contain synthetic fillers, artificial colors, or hidden "flow agents" like magnesium stearate that can actually irritate the gut lining further
Tommasini, R
It's been pushed for women a lot, and we're seeing women go into early menopause
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