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Peer review Peer review information Nature Chemical Biology thanks Jon Fukuto and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Trial Registration Studies are registered at ClinicalTrials.gov (NCT04209049 registered 23 December 2019 and NCT05564104 registered 3 October 2022)

Trubalski M, Markiewicz-Gospodarek A, erebiec M, Poleszak J, Szczotka M, et al

Skin types: All skin types

NMSC rarely migrates into the deeper tissues of the epidermis if unnoticed

In some instances, the concentration of the electrolytes varies over a wide range and depends on the nature and the concentration of each of the ingredients in the final formulation and should be sufficient to stabilize the liposomal membranes