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Human 3D ovarian cancer models reveal Malignant cell-intrinsic and -extrinsic factors that influence CAR T-cell activity

In parallel, ROS reduce nitric oxide bioavailability, promote vascular inflammation, and increase endothelial activation, leading to endothelial dysfunction and impaired vascular reactivity

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Nevertheless, many trials are neither designed nor sufficiently powered to classify participants based on baseline microbiome, diet, or host genotype (576)

Published large human clinical-trial data is not available, so consumer time to results framings sit outside the public regulatory evidence base