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In particular, FOXO1 regulates cell cycle progression, apoptosis, and angiogenesis 144,145 , and promoted both in vivo and in vitro wound healing by preventing oxidative stress in keratinocytes via the upregulation of GPX-2 and GADD45 thus maintaining TGF-1 mediated migration and apoptosis inhibition 146

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Read source 3.Acetyl L-Carnitine Improves Aged Brain Function

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Structural interaction studies need to be performed: although CETSA, MST, and SPR experiments confirmed the physical binding of ACE to PCBP1/2, the precise conformation of the binding site still needs to be resolved by cryo-EM (cryo-electron microscopy) or X-ray crystallography to guide structure-based drug optimization

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