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Similarly, individuals whose lesions show high expression of senescence markers like p16INK4a or SA--Gal activity might be prioritized for senolytic treatments, ensuring a more personalized and effective approach

Ann Neurol (2005) 57(1):6781

Retrospective observational study on riboflavin prophylaxis in child and adolescent migraine

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Most protocols use morning dosing, partly because of the cognitive enhancement intent (effects during waking hours) and partly because some users report mild stimulant-like effects that interfere with sleep if dosed too late