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After 2 weeks of 6-OHDA lesion, rats were treated with either 0.5mg/kg or equivalent volumes of the vehicle ip

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Advanced / Aggressive Protocol (1 mL = ~10.0 mg/mL) Note: The 12 mg dose represents the highest dose tested in Phase 2 trials [3] [4] , producing maximum weight-loss efficacy (~24% body weight at 48 weeks)

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