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The main adverse events reported on AIs (anastrozole, letrozole, and exemestane) were decreased libido (27%), arthralgia (24%), mood disorders (12.5%), asthenia (10%), headaches (6%), anxiety (4.5%), and palpitations (3%)

The combination is used within studies to investigate both local and systemic repair simultaneously

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Because the BPC-157 peptide operates through VEGFR2 and NO pathways that are mechanistically distinct from TB-500s actin-based signaling and GHK-Cus collagen synthesis mechanisms, the three compounds address complementary aspects of tissue repair without documented antagonism in animal studies

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