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As a control, the non-responsive NHS-C7-NHS linker was used to covalently cross-link Mn@mHSA and TI@mHSA, resulting in the control formulation Mn/TI@mHSA-N, which had a similar size to Mn/TI@mHSA (Supplementary Fig

SARS-CoV-2 infection was observed to cause pathological changes including acute respiratory distress syndrome, elevated pro-inflammatory mediator release, dysregulated iron metabolism, and iron overload, with Epi administration significantly improving cardiac status in these patients (51)

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