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Factors such as age, consumption of a processed modern diet, toxin load, and leading a busy, stressed lifestyle decrease its synthesis

Role of glycocalyx in SAP-associated multiple organ dysfunction The pathogenesis of SAP is complex and involves intracellular inflammatory pathways, enzyme activation, endotoxemia, and vascular endothelial damage (Table 3)

doi: 10.1186/s12916-017-0791-y 40

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For GCL, McConnachie et al