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129 In addition, lactylation contributes to hyperplastic scars by increasing Pan Kla and H3K18la levels, activating SLUG, suppressing PTEN, and inhibiting autophagy, which boosts collagen deposition and cell viability in scar fibroblasts

These enkephalins bind to opioid receptors in the gut, creating a potent, natural analgesic effect that can significantly reduce the severe abdominal cramping and visceral pain that many Long COVID and MCAS patients experience after eating

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doi: 10.1016/j.cpb.2021.100203 118 BlackHSBoehmFEdgeRTruscottTG