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In a large meta-analysis of 41 randomized controlled trials including 2,768 patients with systemic inflammatory response syndrome or sepsis, late application (more than 24 hours after the onset of symptoms) of N-acetylcysteine was associated with cardiovascular instability (31)

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Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinsons disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process