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2) Chemical haptens and metal ions can interact with human proteins and activate proinflammatory cytokines and trigger T and B cells in particular TH17 which is known for tissue destruction in autoimmune conditions

The rats were housed in groups in conventional cages with a routine light: dark (14 h:10 h) schedule and a monitored room temperature (27 2C), with unlimited access to food and water

doi: 10.1111/j.1365-2796.2009.02160.x 336 StewartJM