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The discovery of the founding members of the other two protein families of uptake regulators came with the study of the regulation diphtheria toxin expression in Corynebacterium diphtheriae (DtxR) 210212 (Section 3.2.7) and nickel uptake regulation in E

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thus, the type of stimulus can determine the kinetics, amounts and/or spectrum of mediators that are released from this cell type

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