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Inflammation persists past week 6

This inhibition prevents the conversion of nicotinamide into 1-methylnicotinamide, effectively rescuing the NAD salvage pathway

Trials have typically used titration periods of about 6 weeks, starting at a lower dose and stepping up to the full maintenance dose

In clinical studies, participants taking Retatrutide experienced up to 24% weight loss over 48 weeks, more than observed with current GLP-1 treatments

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