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Introduction Hepatotoxicity induced by acetaminophen (APAP), a widely used analgesic and antipyretic, presents major health care challenges in Western societies (Fagan and Wannan, APAP is mostly detoxified via phase II metabolism

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This variability may reflect differences in local microenvironmental conditions and responsiveness to treatment 46

In addition, UCP2 expression was one of the genes that discriminated AD-A and AD-N LCLs using canonical discriminant analysis [22]