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Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

Impairment of the PINK1/Parkin pathway results in failure to clear damaged mitochondria in a timely manner, and these dysfunctional mitochondria become a sustained source of ROS, further exacerbating the lipid peroxidation burden (84)

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Those tend to reflect experiences within broader integrative wellness programs, rather than findings from controlled clinical trials