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593,594 M2-polarized macrophages show increased production of itaconate, which supports their anti-inflammatory function

An alternate possibility is that cytosolic NADPH manipulation ultimately affects matrix NADPH status through metabolite shuttles, which are used to convey reducing equivalents across the mitochondrial membranes by coupling mitochondrial redox reactions with their cytosolic counterparts (for example, using the transport of citrate to couple IDH2 and IDH1) (Taylor, 2017)

Baicalin and puerarin reverse epithelial-mesenchymal transition via the TGF-1/Smad3 pathway in vitro