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, IL-6, IL-1, TNF-, and PGE2 )and serum lipopolysaccharides levels [216,217,218,219,220] and disrupting the intestinal environment, including reducing the diversity of intestinal microorganisms [216, 217] and fecal SCFAs [216, 217, 221], and regulating intestinal PH value [221] and oxidative stress through glycoxidation (NO, protein carbonyl (PCO), MPO and alkaline phosphatase (ALP)) [220, 221]
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Glutathione alters this pathway in two ways: Copper Chelation and Dopaquinone Blockade: Glutathione directly binds to the copper ions at the active site of the tyrosinase enzyme, temporarily deactivating it
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