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Glial cells (astrocytes and microglia) play important roles in maintaining CNS homeostasis through some processes, including reduction of oxidative stress

We verified the impact of ACTL6A on GSH synthesis and confirmed that ACTL6A KD led to reduced expression of certain genes (GCLC, GPX2, GPX4, SLC7A11, SLC1A5, GSS, GLS, etc.) involved in the GSH synthesis pathway (Supplementary Fig

Conversely, the restoration or enhancement of mitophagy would paradoxically attenuate Erastin-induced ROS accumulation, undermining its ferroptosis-promoting effects

Wang H, Sun Y, Yi J, Fu J, Di J, del Carmen AA, et al

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Tf interacts with its receptors (TfR1 and TfR2) to establish a tightly regulated feedback control mechanism