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Close inspection of our SNIP1-P-SF3B1 interaction model also indicates that E366 is in close proximity to the binding interface and its mutation to glycine (E366G) induces most likely local conformational changes in the FHA domain leading to suboptimal P-SF3B1 binding (Fig

Specifically, the salivary microbiota of patients with colorectal polyps showed an increased abundance of harmful bacteria including P.g, F.n, Leptotrichia wadei, Prevotella intermedia, and Megasphaera micronuciformis , while beneficial bacteria such as Prevotella nanceiensis decreased (Zhang et al., 2023)