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Furthermore, we assumed that this effect was independent of p53, given that the plethora of models with different p53 statuses all show similar phenotypes

Animal studies on diabetic rat models revealed decreased microvascular density in the testes, reduced blood perfusion, and significantly impaired sperm production [260]

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Moreover, GI comorbidities such as IBS are frequently observed in CFS/ME, further supporting the hypothesis that gut microbiota imbalances are not merely a consequence of illness but may actively contribute to its pathogenesis (He et al., 2023)

Microbiota mitochondria disorders as hubs for early age-related macular degeneration