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Furthermore, by enhancing sleep quality, DSIP indirectly supports cardiovascular health, as restorative sleep is essential for maintaining heart function and reducing inflammation

These GEFs and GAPs relay signals from various surface receptors, including NMDARs

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The third mechanism is systemic anti-inflammatory signaling, which reduces the inflammatory load that would otherwise slow the structural remodeling process in tendons, ligaments, and muscle

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Management includes lactulose, melatonin, and behavioral therapies and mindfulness