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IN DFO in rats resulted in drug concentration in the cortex approximately 10-fold higher than an equivalent intravenous dose, with lower systemic concentrations and systemic side effects ( A portion of intranasally delivered DFO travels directly into the brain, whereas the rest is systemically absorbed via the nasal mucosa

Additives: Silicon dioxide, magnesium stearate

9) subsequently reacts with an aromatic hydroxylamine to form ester that can degrade to produce a reactive nitrenium ion (Parkinson, 2001)

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EC 6.3.2.2) catalyst of the rate-limiting step of the -glutamylcycle leading to formation of glutathione (l--glutamyl-l-cysteinyl-glycine