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These alterations, along with elevated levels of the epidermal growth factor receptor [EGFR] and decreased P 53 , P 16 , and Rb- gene expression, are crucial players in developing squamous cell carcinoma [54]

Since the diagnosis is based on imaging exams, SARS is likely to be underreported in low-income countries, where the resources to obtain chest radiographs and measure arterial blood gases are limited [6]

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Peer review Peer review information Nature Cell Biology thanks Pavel Ivanov and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Signal Transduct Target Ther