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Early trials reported it to be generally well tolerated at low doses, but these studies were small and of short duration

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Gene regulation of these pathways involves a complex interplay of transcription factors (e.g., RIN, NOR, and HY5) and phytohormones (e.g., ethylene and abscisic acid), which modulate expression patterns during fruit development and stress responses

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In tumor cells, where intracellular GSH levels are often elevated, this reductive environment may facilitate metal-catalyzed redox cycling and paradoxically intensify oxidative stress