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Pretreatment of capsaicin reduces the levels of pro-inflammatory cytokines IL-1 and IL-6 in brain tissue stimulated by ibotenate, and inhibits the activity of brain mast cells in a dose-dependent manner [193]

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It plays a role in conditions like PCOS and endometriosis, and tends to increase naturally with age

Further, berberine nanoparticles could significantly reverse the increased levels of NO and MDA, as well as the enhanced activity of pro-oxidant enzyme MPO in STZ-induced GDM rats

Studies have shown that Hydroxysafflor Yellow A protects PC12 cells from OGD/R injury by inhibiting ferroptosis, offering new strategies for treating degenerative diseases such as cerebral ischemia, though this has yet to be validated in animal models ( 5.7 Anthocyanidins Anthocyanidins are plant pigments responsible for the red, purple, and blue coloration of flowers and fruits, typically found in glycosylated forms (Cruz et al., 2022