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Thus, the knockdown of NEAT1 improved the level of MMP (see Figure 5A )

Shared Risk Factors Aging Cigarette smoking Physical inactivity How COPD Drives Cardiovascular Disease Persistent systemic inflammation endothelial dysfunction, platelet activation & pro-thrombotic state Impaired gas exchange arterial hypoxemia & myocardial hypoxia contractility, arrhythmias Lung hyperinflation venous return, compressed pulmonary vessels reduced cardiac output Exertional dyspnea reduced physical activity (often worsened by anxiety & depression) CV risk How CVD Worsens COPD Outcomes Alveolar & bronchial edema from LV dysfunction airflow limitation Post-capillary pulmonary hypertension Reduced skeletal muscle oxygen delivery further inactivity & deconditioning Take-home Message COPD is not just a lung disease

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Tobacco is the primary nicotine product that a convenience store carries