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GHK prevented an increase in MCP-1 and nitrotyrosine levels in the hippocampus of sleep-deprived mice suggesting that inflammatory and reactive nitrogen/oxygen species activity could be therapeutic targets for learning impairment associated with short-term sleep deprivation

However, methionine synthase rs1805087 was not a risk factor for the susceptibility and disease severity to ASD in a Chinese population 34

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In humans there is a 49-base-pair insert (a slightly longer insert in rodents) that produces a reading-frame shift during splicing, generating a mature isoform with a unique C-terminal peptide sequence that does not exist in the other IGF-1 variants

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