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Since these two pathways were previously identified as crucial in the AD-related pathway-gene network, we performed cluster analysis on the union of DEGs from all four groups involved in either Neuroactive ligand-receptor interaction or Calcium signaling pathway

3.72 (1.19) in FEP

Annexins are Ca 2+ and membrane binding proteins and several reports also document their activity as Ca 2+ channels [291]

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By interrupting a key proteinprotein interaction that allows senescent cells to persist, FOXO4-DRI offers the potential to selectively eliminate those cells and thus improve tissue function, reduce inflammation, and restore aspects of youthful physiology