Simply, it was argued that the key tenets of this model state that there is a universal genetic program that governs cell death at different stages of development, that a variety of stimuli can elicit or activate this program, and that, even though many transduction mechanisms are involved, eventually apoptosis requires activation of a downstream convergent, final pathway [119126]
Giraldo, E., Lloret, A., Fuchsberger, T
Thus, we reasoned that Gclc expression and GSH are needed upon activation of FoB
Kondo N, Ishii Y, Kwon Y-W, Tanito M, Horita H, Nishinaka Y, Nakamura H, Yodoi J (2004) Redox-sensing release of human thioredoxin from T lymphocytes with negative feedback loops
Over the short term, anything can happen
Altered human oligodendrocyte heterogeneity in multiple sclerosis