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Therefore, enhanced glutaminolysis might eventually contribute to the initiation and progression of cancer by stimulating cell growth via the mTORC1 pathway and enhancing aerobic glycolysis while disrupting the proper elimination of misfolded proteins, damaged DNA and organelles through the inhibition of autophagy and the DNA damage response 166

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Glutamate undergoes deamination, an oxidative reaction catalysed by glutamate dehydrogenase, [18] as follows: Ammonia (as ammonium) is then excreted predominantly as urea, synthesised in the liver

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Farrugia, G., Bannister, W