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Large-scale trials, notably AREDS and AREDS2, support zincs efficacy in slowing AMD progression, especially in combination with antioxidants such as vitamins C and E and -carotene [429,430,431]

Because comprehensive long term safety data is limited, researchers approach experimentation cautiously and document all observed biological responses

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Adding a second peptide without understanding how the mechanisms overlap or compound side effects is how people end up with an intolerable protocol they can't troubleshoot

Data in human subjects are mostly observational and lack randomized controlled trials