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In the ARC, there are two distinct neuronal populations: one is a group of neurons coexpressing orexigenic neuropeptides, including neuropeptide Y (NPY) and agouti-related peptide (AgRP), and the other is a subset of neurons expressing anorexigenic neuropeptides, including proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART)

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demonstrated that a related analog, AHK-Cu, stimulated the elongation of human hair follicles, firmly establishing the role of copper peptides in ex vivo research [23]

Angiogenesis / blood flow Both peptides are investigated in animal models for angiogenesis, the new-blood-vessel formation thought to support tissue repair