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In murine models, cyclosporine, functioning as a CypA inhibitor, diminishes the CypA-NF-B-MMP-9 pathway associated with BBB degradation and neurodegenerative changes

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Another name for vitamin B3 is nicotinamide

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Clinical studies in elderly humans confirm these findings

The CUD participants were recruited in this ancillary study from a wider sample of treatment-seeking patients participating in the Brainswitch project, a double-blind, sham-controlled trial testing the ability of repetitive transcranial magnetic stimulation to treat CUD (preliminary data published in Martinotti et al