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PMID: 26236730 Pickart L, Margolina A

Animal toxicology studies spanning three decades have found no evidence of mutagenic, genotoxic, or carcinogenic effects

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In addition, Srebp-1 expression in the liver by re-feeding was not attenuated in Insr P1195L/ +/HFD mice, indicating that hepatic Srebp-1 expression in the liver by re-feeding and by HFD feeding remains intact under insulin resistance (i.e., is insulin sensitive 3 )

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