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No clinical claims or therapeutic uses are implied

GHK-Cu works through copper-dependent enzyme activity, extracellular matrix signaling, integrin pathways, MAPK/ERK cascades, and direct gene expression modulation

The primer sequences are listed in Table 1

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Preclinical studies that have measured DA in the ventral striatum have shown that opioid withdrawal is associated with decreases in DA [10, 21,22,23,24,25, 51,52,53,54], whereas some studies have reported increases in DA particularly in the dorsal striatum [27, 55]