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Functional enrichment analysis of the 181 genes appropriately represented the established biologic pathways that are regulated by HIF, including glycolysis, angiogenesis and apoptosis (Supplementary Table 2)

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It is believed that the Werner syndrome (WS), which is characterized by severe metabolic dysfunction, dyslipidemia, early atherosclerosis, and insulin resistance diabetes, most closely resembles the aging process (23)

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4th Segmental hyperalgesia to mechanical stimulus in interstitial cystitis/bladder pain syndrome: evidence of central sensitization