The lipid bilayer stabilized GalCer presentation to iNKT cells, which in turn activated DCs and amplified antigen-specific CTL responses
The consequences of this difference have been recognised in the investigation of the toxic mechanisms associated with gout, where the concentrations of UA that induce peripheral microcrystallisation and its related inflammatory reaction are not easily reached in rodents
As an example see Dendritic cells Application Sheet C21 in index
Insufficient mixing (leaves undissolved particles)
Study to Assess Safety and Immune Response of Stage IIB-IV Resected Melanoma After Treatment With MAGE-A3 ASCI (Mel55) ClinicalTrials.gov Identifier: NCT01425749 ( Vaccine Therapy and Interleukin-12 in Treating Patients With Metastatic Melanoma ClinicalTrials.gov Identifier: NCT00054535 ( Gutzmer R, Stroyakovskiy D, Gogas H, Robert C, Lewis K, Protsenko S, et al
[29] Management [edit] Treatment of Graves' disease includes antithyroid drugs that reduce the production of thyroid hormone, radioiodine (radioactive iodine I-131), and thyroidectomy (surgical excision of the gland)