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It's been purified by distillation or equivalent methods, stripping out pyrogens (fever-causing substances), particles, and microbial contamination

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This effect was associated with upregulation of hydroxyindole-O-methyltransferase (HIOMT), a key enzyme in melatonin biosynthesis (Khavinson & Anisimov, Neuroendocrinology Letters, 2000)