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Rather than relying on glucose (sugar) like many other cells in the body, these gut cells crave glutamine to maintain their strength and structure

Interestingly, a recent study showed that CDK4/6 inhibitors blocked SLC7A11 expression by inhibiting SP1 binding to the SLC7A11 promoter and induced ferroptosis in luminal A breast cancer cells [31]

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Lee WH, Morton RA, Epstein JI, Brooks JD, Campbell PA, Bova GS, Hsieh WS, Isaacs WB, Nelson WG (1994) Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis

Front Endocrinol (Lausanne) 13:1092837