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Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

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10.1016/S0891-5849(99)00177-X

In the present review, the emphasis on cortical and hippocampal regions reflects their central relevance to glutamatergic neurotransmission and to the pathophysiology of neurodegenerative and neuropsychiatric disorders, rather than the sites of highest absolute GlyT1 expression (Fig

354 Ammonium is mainly produced in the gut by amino acid deamination with subsequent conversion to ammonium by urease containing bacteria and is detoxified in the liver by the urea cycle enzymes and by glutamine synthetase, highly expressed in hepatocytes