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FOXO4-DRI is among the highest-risk research peptides from an evidence-to-risk standpoint: it has never been tested in humans, no human pharmacokinetic data exists, and as a senolytic it carries theoretical risks specific to its mechanism

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2016;106:1420-1431.e7

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Previous studies have revealed that alterations in the mechanisms directing tumor development may initiate or interfere with immune responses in the TME, leading to either immune resistance or dysfunction, and eventually resulting in the tumor's avoidance of the immune system