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Beside possible neuroprotective effects, COX-2 inhibitors increase intestinal permeability that correlates with their potency to inhibit COX-2, thus ultimately leading to local inflammatory side effects (236, 237)

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In vivo , allicin supports host defense by promoting macrophage activation and interferon- (IFN-) signaling

Through optical light-scatter biosensing, architectural changes derived from TNF--induced inflammation were reliably detected in a non-invasive manner, while maintaining a stable culture for over a week (46)

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