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Studies also strongly suggest that an overactive mTOR pathway drives DAMD pathology, with dysregulation in the AMPK and SIRT1/PGC-1 pathways also contributing to metabolic alterations [63,64,65]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Jacques P.F., Chylack L.T., Hankinson S.E., Khu P.M., Rogers G., Friend J., Tung W., Wolfe J.K., Padhye N., Willett W.C., et al

Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimers disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin